NNO Pincer Ligand-Supported Palladium(II) Complexes: Direct Synthesis of Quinazolines via Acceptorless Double Dehydrogenative Coupling of Alcohols

A sustainable approach for the synthesis of substituted quinazolines by sequential acceptorless dehydrogenative coupling 2-aminobenzyl alcohol with alcohols using new Pd(II)-NNO pincer-type complexes as catalysts was reported. Air-stable palladium(II) general formula [Pd(L)(PPh3)] (where L = 4-substituted methyl-2-pyrrolyl benzhydrazone ligands) were synthesized, and their compositions recognized analytical spectral methods (Fourier transform infrared (FT-IR), NMR, high-resolution mass spectrometry (HRMS)). Single-crystal X-ray crystallography confirmed tridentate coordination ligands existence square-planar geometry around metal ion. wide range quinazoline derivatives synthesized from double dehydrogenation benzyl 1.5 mol % catalyst loading a maximum 93% yield. The formation aminobenzaldehyde benzaldehyde intermediates via reaction control experiments.